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References
- Channelopathies from mutations in the cardiac sodium channel protein complex.J Mol Cell Cardiol. 2013; 61: 34-43
- Cardiac sodium channel Na(v)1.5 and interacting proteins: physiology and pathophysiology.J Mol Cell Cardiol. 2010; 48: 2-11
- Sudden infant death syndrome.in: Zipes D.P. Jalife J. Cardiac electrophysiology: from cell to bedside. 6th edition. Elsevier, Philadelphia2014: 975-980
- Auxiliary subunits of voltage-gated ion channels.Neuron. 1994; 12: 1183-1194
- Cypher/ZASP is a novel A-kinase anchoring protein.J Biol Chem. 2013; 288: 29403-29413
- Scaffolding proteins and ion channel diseases.in: Zipes D.P. Jalife J. Cardiac electrophysiology: from cell to bedside. 6th edition. Elsevier, Philadelphia2014: 229-234
- Functional effects of protein kinase C activation on the human cardiac Na+ channel.Circ Res. 1997; 80: 370-376
- Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.Circ Res. 2004; 95: 284-291
- Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model.Biochim Biophys Acta. 2013; 1833: 886-894
- SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.Circ Res. 2011; 108: 294-304
- Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.Am J Physiol Heart Circ Physiol. 2008; 295: H667-H676
- Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias.Circulation. 2007; 116: 2260-2268
- A mutation in telethonin alters nav1.5 function.J Biol Chem. 2008; 283: 16537-16544
- Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.Proc Natl Acad Sci U S A. 2004; 101: 17533-17538
- Calmodulin mutations associated with recurrent cardiac arrest in infants.Circulation. 2013; 127: 1009-1017
- Syntrophin proteins as Santa Claus: role(s) in cell signal transduction.Cell Mol Life Sci. 2013; 70: 2533-2554
- Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.Nature. 2002; 416: 337-339
- Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin.Circ Res. 2006; 99: 407-414
- Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.Proc Natl Acad Sci U S A. 2008; 105: 9355-9360
- The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.J Biol Chem. 2006; 281: 23341-23348
- Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.Circulation. 2007; 115: 483-492
- alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.Circ Arrhythm Electrophysiol. 2008; 1: 193-201
- Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current.Circ Arrhythm Electrophysiol. 2009; 2: 667-676
- Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome.Am J Physiol Heart Circ Physiol. 2013; 304: H994-H1001
- LQTS-associated mutation A257G in alpha1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype.Cardiogenetics. 2011; 1: 55-59
- Caveolae, ion channels and cardiac arrhythmias.Prog Biophys Mol Biol. 2008; 98: 149-160
- Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes.FEBS Lett. 1998; 434: 127-134
- Caveolin-3 in muscular dystrophy.Hum Mol Genet. 1998; 7: 871-877
- Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome.Circulation. 2006; 114: 2104-2112
- Novel mechanism for sudden infant death syndrome: persistent late sodium current secondary to mutations in caveolin-3.Heart Rhythm. 2007; 4: 161-166
- Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain.J Biol Chem. 1997; 272: 28187-28190
- Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A.J Mol Cell Cardiol. 2013; 61: 102-110
- The interaction of caveolin 3 with the inward rectifier channel Kir2.1; physiology and pathology related to LQT9.J Biol Chem. 2013; 288: 17472-17480
- Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1).J Mol Biol. 2006; 357: 858-869
- Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3.Circulation. 2002; 105: 707-713
- Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome.Circulation. 2007; 116: 2253-2259
- GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A.Am J Physiol Heart Circ Physiol. 2009; 297: H1446-H1452
- Cardiac Na+ current regulation by pyridine nucleotides.Circ Res. 2009; 105: 737-745
- Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel.Circ Res. 2010; 107: 967-974
- Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome.Circ J. 2008; 72: 1705-1706
- Common variants in CASQ2, GPD1L, and NOS1AP are significantly associated with risk of sudden death in patients with coronary artery disease.Circ Cardiovasc Genet. 2011; 4: 397-402
- Identification of a conserved loop in Mog1 that releases GTP from Ran.Traffic. 2001; 2: 804-811
- Identification and characterization of the human MOG1 gene.Gene. 2001; 266: 45-56
- Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5.J Biol Chem. 2008; 283: 6968-6978
- MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.Circ Arrhythm Electrophysiol. 2013; 6: 392-401
- MOG1: a new susceptibility gene for Brugada syndrome.Circ Cardiovasc Genet. 2011; 4: 261-268
- A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.Can J Cardiol. 2011; 27: 523
- Brugada syndrome and p.E61X_RANGRF.Cardiol J. 2014; 21: 121-127
- Plakophilins: multifunctional scaffolds for adhesion and signaling.Curr Opin Cell Biol. 2009; 21: 708-716
- Structure, function, and regulation of desmosomes.Prog Mol Biol Transl Sci. 2013; 116: 95-118
- Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy.Circulation. 2006; 113: 1650-1658
- Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.J Mol Cell Cardiol. 2005; 38: 475-483
- Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.Heart Rhythm. 2013; 10: 412-419
- Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.Circ Res. 2009; 105: 523-526
- Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.Cardiovasc Res. 2012; 95: 460-468
- Missense mutations in plakophilin-2 cause sodium current deficit and associate with a Brugada syndrome phenotype.Circulation. 2014; 129: 1092-1103
- Desmosomes and the sodium channel complex: Implications for arrhythmogenic cardiomyopathy and Brugada syndrome.Trends Cardiovasc Med. 2014; 24: 184-190
- Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins.J Biol Chem. 2000; 275: 38474-38481
- A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5.Circ Arrhythm Electrophysiol. 2012; 5: 1098-1107
- Insights into the molecular evolution of the PDZ/LIM family and identification of a novel conserved protein motif.PLoS One. 2007; 2: e189
- Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction.J Am Coll Cardiol. 2003; 42: 2014-2027
- ALP/Enigma PDZ-LIM domain proteins in the heart.J Mol Cell Biol. 2010; 2: 96-102
- Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction.Circ Arrhythm Electrophysiol. 2012; 5: 1017-1026
- 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5.Circ Res. 2006; 98: 1538-1546
- Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.Biochemistry. 2010; 49: 166-178
- Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions.Physiology (Bethesda). 2007; 22: 342-350
- Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway.J Cell Biol. 2008; 180: 173-186
- Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes.Circulation. 2001; 103: 1303-1310
- Late currents affect kinetics for heart and skeletal Na channel α and β1 subunits expressed in HEK293 cells.J Mol Cell Cardiol. 2002; 34: 1029-1039
- Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.J Physiol Sci. 2009; 59: 217-225
- Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects.J Mol Cell Cardiol. 2003; 35: 549-557
- Functional association of the β1 subunit with human cardiac (hH1) and rat skeletal muscle (μ1) sodium channel α subunits expressed in Xenopus oocytes.J Gen Physiol. 1995; 106: 1171-1191
- Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.J Mol Cell Cardiol. 2007; 43: 636-647
- Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.J Biol Chem. 2006; 281: 25875-25881
- Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure.Am J Physiol Heart Circ Physiol. 2011; 301: H1596-H1605
- Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties.Acta Physiol (Oxf). 2010; 198: 47-59
- The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart.J Physiol. 2001; 537: 693-700
- Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties.Prog Biophys Mol Biol. 2008; 98: 251-266
- SCN4B-encoded sodium channel {beta}4 subunit in congenital long-QT syndrome.Circulation. 2007; 116: 136-142
- Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy.Circ Res. 2009; 104: 1283-1292
- A beta(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.J Clin Invest. 2010; 120: 3508-3519
- Calmodulin mediates Ca2+ sensitivity of sodium channels.J Biol Chem. 2004; 279: 45004-45012
- Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.J Mol Biol. 2011; 406: 106-119
- A calcium sensor in the sodium channel modulates cardiac excitability.Nature. 2002; 415: 442-447
- Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes.Cardiovasc Res. 2010; 85: 454-463
- Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease.Circulation. 2012; 126: 2084-2094
- Cardiac gap junctions and connexins: their role in atrial fibrillation and potential as therapeutic targets.Cardiovasc Res. 2002; 54: 270-279
- Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.J Biol Chem. 2004; 279: 40748-40754
- Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice.Heart Rhythm. 2012; 9: 600-607
- Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes.Cardiovasc Res. 2012; 95: 409-418
- Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice.Cardiovasc Res. 2011; 89: 320-328
- Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.Circ Res. 2011; 109: 775-782
- Syntrophin gamma 2 regulates SCN5A Gating by a PDZ domain-mediated interaction.J Biol Chem. 2003; 278: 1915-1923
- Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.Biochem Biophys Res Commun. 2006; 348: 1455-1462
- Deciphering the binding of caveolin-1 to client protein endothelial nitric oxide synthase (eNOS): scaffolding sub-domain identification, interaction modeling, and biological significance.J Biol Chem. 2014; 289: 13273-13283
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Published online: September 25, 2014
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