Advertisement

Multisite Left Ventricular Pacing in Cardiac Resynchronization Therapy

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Cardiac Electrophysiology Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Tracy C.M.
        • Epstein A.E.
        • Darbar D.
        • et al.
        2012 ACCF/AHA/HRS Focused Update Incorporated Into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities.
        J Am Coll Cardiol. 2013; 61https://doi.org/10.1016/j.jacc.2012.11.007
        • Bristow M.R.
        • Saxon L.A.
        • Boehmer J.
        • et al.
        Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.
        N Engl J Med. 2004; 350: 2140-2150
        • Cleland J.G.F.
        • Daubert J.-C.
        • Erdmann E.
        • et al.
        The effect of cardiac resynchronization on morbidity and mortality in heart failure.
        N Engl J Med. 2005; 352: 1539-1549
        • Moss A.J.
        • Hall W.J.
        • Cannom D.S.
        • et al.
        Cardiac-resynchronization therapy for the prevention of heart-failure events.
        N Engl J Med. 2009; 361: 1329-1338
        • Young J.B.
        • Abraham W.T.
        • Smith A.L.
        • et al.
        Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial.
        JAMA. 2003; 289: 2685-2694
        • Tanaka H.
        • Hara H.
        • Saba S.
        • et al.
        Prediction of response to cardiac resynchronization therapy by speckle tracking echocardiography using different software approaches.
        J Am Soc Echocardiogr. 2009; 22: 677-684
        • Tanaka H.
        • Nesser H.-J.
        • Buck T.
        • et al.
        Dyssynchrony by speckle-tracking echocardiography and response to cardiac resynchronization therapy: results of the Speckle Tracking and Resynchronization (STAR) study.
        Eur Heart J. 2010; 31: 1690-1700
        • Adelstein E.C.
        • Saba S.
        Baseline scintigraphic abnormalities by myocardial perfusion imaging predict echocardiographic response to cardiac resynchronization therapy in nonischemic cardiomyopathy.
        Clin Cardiol. 2008; 31: 217-224
        • Varma N.
        • Auricchio A.
        • Connolly A.T.
        • et al.
        The cost of non-response to cardiac resynchronization therapy: characterizing heart failure events following cardiac resynchronization therapy.
        Europace. 2021; 00: 1-10
        • Bertini M.
        • Höke U.
        • van Bommel R.J.
        • et al.
        Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival.
        Eur Heart J Cardiovasc Imaging. 2013; 14https://doi.org/10.1093/ehjci/jes290
        • Gold M.R.
        • Thébault C.
        • Linde C.
        • et al.
        Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the resynchronization reverses remodeling in systolic left ventricular dysfunction (REVERSE) study.
        Circulation. 2012; 126https://doi.org/10.1161/CIRCULATIONAHA.112.097709
        • Abraham W.T.
        • Fisher W.G.
        • Smith A.L.
        • et al.
        Cardiac resynchronization in chronic heart failure.
        N Engl J Med. 2002; 346: 1845-1853
        • Rickard J.
        • Bassiouny M.
        • Cronin E.M.
        • et al.
        Predictors of response to cardiac resynchronization therapy in patients with a non-left bundle branch block morphology.
        Am J Cardiol. 2011; 108https://doi.org/10.1016/j.amjcard.2011.07.017
        • Saba S.
        • Marek J.
        • Alam M.B.
        • et al.
        Influence of QRS duration on outcome of death or appropriate defibrillator therapy by strategy of left ventricular lead placement in cardiac resynchronization therapy recipients.
        J Interv Card Electrophysiol. 2014; 41: 211-215
        • Barsheshet A.
        • Goldenberg I.
        • Moss A.J.
        • et al.
        Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT.
        Eur Heart J. 2011; 32https://doi.org/10.1093/eurheartj/ehq407
        • Daya H.A.
        • Alam M.B.
        • Adelstein E.
        • et al.
        Echocardiography-guided left ventricular lead placement for cardiac resynchronization therapy in ischemic vs nonischemic cardiomyopathy patients.
        Hear Rhythm. 2014; 11https://doi.org/10.1016/j.hrthm.2014.01.023
        • Adelstein E.C.
        • Tanaka H.
        • Soman P.
        • et al.
        Impact of scar burden by single-photon emission computed tomography myocardial perfusion imaging on patient outcomes following cardiac resynchronization therapy.
        Eur Heart J. 2011; 32: 93-103
        • Beela A.S.
        • Duchenne J.
        • Petrescu A.
        • et al.
        Sex-specific difference in outcome after cardiac resynchronization therapy.
        Eur Heart J Cardiovasc Imaging. 2019; 20https://doi.org/10.1093/ehjci/jey231
        • Herz N.D.
        • Engeda J.
        • Zusterzeel R.
        • et al.
        Sex differences in device therapy for heart failure: utilization, outcomes, and adverse events.
        J Womens Health. 2015; 24https://doi.org/10.1089/jwh.2014.4980
        • Varma N.
        • Lappe J.
        • He J.
        • et al.
        Sex-Specific response to cardiac resynchronization therapy: effect of left ventricular size and QRS duration in left bundle branch block.
        JACC Clin Electrophysiol. 2017; 3https://doi.org/10.1016/j.jacep.2017.02.021
        • Khan F.Z.
        • Virdee M.S.
        • Palmer C.R.
        • et al.
        Targeted left ventricular lead placement to guide cardiac resynchronization therapy: the TARGET study: a randomized, controlled trial.
        J Am Coll Cardiol. 2012; 59https://doi.org/10.1016/j.jacc.2011.12.030
        • Saba S.
        • Marek J.
        • Schwartzman D.
        • et al.
        Echocardiography-guided left ventricular lead placement for cardiac resynchronization therapy: results of the Speckle Tracking assisted resynchronization therapy for electrode region trial.
        Circ Heart Fail. 2013; 6: 427-434
        • Marek J.J.
        • Saba S.
        • Onishi T.
        • et al.
        Usefulness of echocardiographically guided left ventricular lead placement for cardiac resynchronization therapy in patients with intermediate QRS width and non-left bundle branch block morphology.
        Am J Cardiol. 2014; 113: 107-116
        • Gold M.R.
        • Birgersdotter-Green U.
        • Singh J.P.
        • et al.
        The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy.
        Eur Heart J. 2011; 32https://doi.org/10.1093/eurheartj/ehr329
        • Cazeau S.
        • Ritter P.
        • Lazarus A.
        • et al.
        Multisite pacing for end-stage heart failure: early experience.
        Pacing Clin Electrophysiol. 1996; 19https://doi.org/10.1111/j.1540-8159.1996.tb03218.x
        • Cazeau S.
        • Leclercq C.
        • Lavergne T.
        • et al.
        Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay.
        N Engl J Med. 2001; 344: 873-880
        • Sohal M.
        • Shetty A.
        • Niederer S.
        • et al.
        Mechanistic insights into the benefits of multisite pacing in cardiac resynchronization therapy: the importance of electrical substrate and rate of left ventricular activation.
        Hear Rhythm. 2015; 12https://doi.org/10.1016/j.hrthm.2015.07.012
        • Thibault B.
        • Dubuc M.
        • Khairy P.
        • et al.
        Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead.
        Europace. 2013; 15https://doi.org/10.1093/europace/eus435
        • Netzler P.
        • Cuoco F.
        • George A.
        • et al.
        The effect of left ventricular sensing electrode position on electrical delay in cardiac resynchronization therapy.
        J Am Coll Cardiol. 2014; 63https://doi.org/10.1016/s0735-1097(14)60448-4
        • Heckman L.I.B.
        • Kuiper M.
        • Anselme F.
        • et al.
        Evaluating multisite pacing strategies in cardiac resynchronization therapy in the preclinical setting.
        Hear Rhythm O2. 2020; 1https://doi.org/10.1016/j.hroo.2020.03.003
        • Siciliano M.
        • Migliore F.
        • Badano L.
        • et al.
        Cardiac resynchronization therapy by multipoint pacing improves response of left ventricular mechanics and fluid dynamics: a three-dimensional and particle image velocimetry echo study.
        Europace. 2017; 19https://doi.org/10.1093/europace/euw331
        • Osca J.
        • Alonso P.
        • Cano O.
        • et al.
        The use of multisite left ventricular pacing via quadripolar lead improves acute haemodynamics and mechanical dyssynchrony assessed by radial strain speckle tracking: initial results.
        Europace. 2016; 18https://doi.org/10.1093/europace/euv211
        • Zanon F.
        • Marcantoni L.
        • Baracca E.
        • et al.
        Hemodynamic comparison of different multisites and multipoint pacing strategies in cardiac resynchronization therapies.
        J Interv Card Electrophysiol. 2018; 53https://doi.org/10.1007/s10840-018-0362-y
        • Ricciardi D.
        • Giacomo D.G.
        • Antonio B.
        • et al.
        169-04: non invasive hemodynamic optimization of multisite left ventricular pacing: a multicenter pilot study.
        EP Eur. 2016; 18https://doi.org/10.1093/europace/18.suppl_1.i115c
        • Rinaldi C.A.
        • Leclercq C.
        • Kranig W.
        • et al.
        Improvement in acute contractility and hemodynamics with multipoint pacing via a left ventricular quadripolar pacing lead.
        J Interv Card Electrophysiol. 2014; 40https://doi.org/10.1007/s10840-014-9891-1
        • Akerström F.
        • Narváez I.
        • Puchol A.
        • et al.
        Estimation of the effects of multipoint pacing on battery longevity in routine clinical practice.
        Europace. 2018; 20https://doi.org/10.1093/europace/eux209
        • Antoniou K.
        • Chrysohoou C.
        • Dilaveris P.
        • et al.
        Optimization in cardiac resynchronization therapy with quadripolar leads offer improvement in cardiac energetics in heart failure patients compared with bipolar leads: HUMVEE Clinical Trial.
        Eur Heart J. 2020; 41https://doi.org/10.1093/ehjci/ehaa946.0888
        • Sterliński M.
        • Sokal A.
        • Lenarczyk R.
        • et al.
        In heart failure patients with left bundle branch block single lead multispot left ventricular pacing does not improve acute hemodynamic response to conventional biventricular pacing. A multicenter prospective, interventional, non-randomized study.
        PLoS One. 2016; 11https://doi.org/10.1371/journal.pone.0154024
        • Niazi I.
        • Baker J.
        • Corbisiero R.
        • et al.
        Safety and efficacy of multipoint pacing in cardiac resynchronization therapy: the MultiPoint pacing trial.
        JACC Clin Electrophysiol. 2017; 3https://doi.org/10.1016/j.jacep.2017.06.022
        • Leclercq C.
        • Burri H.
        • Curnis A.
        • et al.
        Rationale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP–PHASE II).
        Am Heart J. 2019; 209https://doi.org/10.1016/j.ahj.2018.12.004
        • Leclercq C.
        • Burri H.
        • Curnis A.
        • et al.
        Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE-CRT MPP) study: results from phase I.
        Eur Heart J. 2019; 40https://doi.org/10.1093/eurheartj/ehz109
        • Abdelhadi R.
        • Adelstein E.
        • Voigt A.
        • et al.
        Measures of left ventricular dyssynchrony and the correlation to clinical and echocardiographic response after cardiac resynchronization therapy.
        Am J Cardiol. 2008; 102: 598-601
      1. Zanon F, Marcantoni L, Baracca E, et al. Optimization of left ventricular pacing site plus multipoint pacing improves remodeling and clinical response to cardiac resynchronization therapy at 1 year. Heart Rhythm. 2016 Aug;13(8):1644–51.

      2. Forleo GB, Santini L, Giammaria M, et al. Multipoint pacing via a quadripolar left-ventricular lead: preliminary results from the Italian registry on multipoint left-ventricular pacing in cardiac resynchronization therapy (IRON-MPP). Europace. 2017 Jul 1;19(7):1170–1177.

      3. Antoniou CK, Dilaveris P, Chrysohoou C, et al. Multipoint left ventricular pacing effects on hemodynamic parameters and functional status: HUMVEE single-arm clinical trial (NCT03189368). Hellenic J Cardiol. 2021 Mar 4:S1109-9666(21)00049-X. doi:10.1016/j.hjc.2021.02.012.

      4. Saba S, Nair D, Ellis CR, et al. Strategic Management to Improve CRT Using Multi-Site Pacing (SMART-MSP) Investigators.Usefulness of Multisite Ventricular Pacing in Nonresponders to Cardiac Resynchronization Therapy. Am J Cardiol. 2022 Feb 1;164:86–92.